General Information, Immunochemistry, Test Utilization

Protein Electrophoresis Orderable Changes

As of August 26, 2020, the following tests will be obsoleted or made as lab orderables only.  This was implemented to streamline protein electrophoresis orders and ensure that patients receive the recommended testing for the assessment of plasma cell proliferative diseases.

In addition to streamlining protein electrophoresis orders, order questions have been implemented to the available tests to access the reason for ordering to ensure that the proper reflex testing is applied.

For more information, see the lab test directory under the available tests for a protein electrophoresis orders tip sheet entitled “Orders- Protein Orderable Changes

Obsoleted:

  • Electrophoresis, Serum (LAB119)
  • Protein Electrophoresis, Urine (LAB438)
  • Protein Electrophoresis, 24 hour Urine (LAB10156)

Lab orderables only:

  • Immunofixation, Serum (LAB156)
  • Immunofixation, Urine (LAB801)

Available tests:

ORDER  QUESTIONS

  • For SERUM protein electrophoresis, four questions are available.

    • Monitoring: Useful for the routine follow-up for patients diagnosed with a monoclonal gammopathy (plasma cell proliferative disorder). Includes serum protein electrophoresis with reflex to serum immunofixation if indicated, such as in the case of characterizing a stringent complete response or in the presence of a new serum abnormality.
    • Screen, General: Useful for the screening of patients with a general suspicion of monoclonal gammopathy (plasma cell proliferative disorder). Includes serum protein electrophoresis with reflex to serum immunofixation in the presence of an abnormal serum protein electrophoresis.
    • Screen, AL Amyloid: Useful for the screening of patients with suspicion of AL Amyloid. Includes serum protein electrophoresis plus serum immunofixation.
    • Screen, Neuropathy (POEMS): Useful for the screening of patients with suspicion of neuropathy (POEMS). Includes serum protein electrophoresis plus serum immunofixation.
  • For URINE protein electrophoresis, three questions are available.

    • Monitoring: Useful for the routine follow-up for patients diagnosed with a monoclonal gammopathy (plasma cell proliferative disorder). Includes urine protein electrophoresis with reflex to urine immunofixation if indicated such as if a new abnormality is present.
    • Screen, General: Useful for the screening of patients with a general suspicion of monoclonal gammopathy (plasma cell proliferative disorder). Urine protein electrophoresis with reflex to urine immunofixation in the presence of an abnormal urine protein electrophoresis.
    • Screen, AL Amyloid: Useful for the screening of patients with suspicion of AL Amyloid. Includes urine protein electrophoresis plus serum immunofixation.
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