NTRK Gene Fusion is Available at Corewell Health West Molecular Diagnostics Laboratory

NTRK genes (NTRK1, NTRK2, NTRK3) encode tropomyosin receptor kinases (TRK) family of tyrosine protein kinase receptors TRK A, B and C. Trk receptors are composed of extracellular domain regulated by neurotrophins, and intracellular tyrosine kinase domain that activates downstream signaling. Trk receptors play essential roles in the development and maintenance of nervous system. NTRK gene fusion events join the catalytic tyrosine kinase domain of the TRK protein with the dimerization domain of fusion partner to confer ligand-independent downstream signaling which may promote cancer cells to grow.

NTRK Gene Fusion by Archer® FusionPlex platform can detect RNA transcripts of NTRK1/2/3 gene fusion with any partner genes. TRK inhibitors treatment may be considered in patients with NTRK gene fusion positive disease for various types of pediatric and adult cancers.

RNA-based sequencing is the most reliable method for NTRK gene fusion detection. Immunohistochemistry by pan-TRK antibody can provide fast screening for tumors with positive TRK expression. However, RNA based molecular testing is necessary to confirm the presence of true NTRK Gene Fusion event.

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TEST INFORMATION

NTRK Gene Fusion, Epic order code: LAB1230897, CPT 81194