General Information, Immunochemistry

IgE Allergy Testing Update: Addition of New Peanut Component rAra h 6

As of January 8th 2020 the peanut component rAra h 6 will be added to the following testing panels.

IgE Peanuts, Component Allergen Panel (LAB3424)

IgE Peanut, Component Allergen Panel if Positive (LAB3423)

Currently, the testing panel LAB3423 is reflexed after a positive IgE peanut (LAB211622) and consists of peanut components.

● Ara h 1 IgE

● Ara h 2 IgE

● Ara h 3 IgE

● Ara h 8 IgE

● Ara h 9 IgE

More than 13 peanut components have been identified and accepted by the Allergen Nomenclature Subcommittee of the International Union of Immunological Societies (IUIS).  The most important and clinically relevant components are Ara h 1, 2, 3, 6, 8, and 9.  Peanut component rAra h 6 along with rAra h 2 appeared to be the most potent allergens and sensitization to these components is indicative for severe allergic reactions.

 

REFERENCES

  1. van der Valk JPM, Schreurs MWJ, El Bouch R, Arends NJT, de Jong NW. Mono-sensitisation to peanut component Ara h 6: a case series of five children and literature review. Eur J Pediatr. 2016;175(9):1227–1234. doi:10.1007/s00431-016-2733-7.
  2. Kukkonen, Anna & Pelkonen, Anna & Mäkinen‐Kiljunen, Soili & Voutilainen, Helena & Mäkelä, Mika. (2015). Ara h 2 and Ara 6 are the best predictors of severe peanut allergy: A double-blind placebo-controlled study. Allergy. 70. 10.1111/all.12671.

TEST INFORMATION

IgE Peanut – Epic Code #LAB2111622, Interface Code #10853, CPT #86003

IgE Peanuts, Component Allergen Panel – Epic Code #LAB3424, Interface Code #11721, CPT #86008

IgE Peanut, Component Allergen Panel if Positive – Epic Code #LAB3423, Interface Code #11720, CPT #86003 with additional #86008 if reflexed.

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