Effective May 20, 2019, Spectrum Health Regional Laboratory Cytogenetics Department is pleased to announce the launch of a new microarray platform AffymetrixTM Cytoscan® HD. The Affymetrix Cytoscan HD is designed for the accurate and comprehensive analysis of chromosomal variants in the human genome. Cytoscan HD was designed to measure copy number variations, to detect allelic imbalances (i.e. UPD, uniparental disomy), and to genotype the sample by SNP analysis (single nucleotide polymorphism). The Cytoscan HD solution is based on the independent analysis of two types of molecular markers: 1.7 million oligonucleotide probes and 750,000 SNP probes. The array covers every gene region known to be involved in cytogenetic abnormalities, including 255 recognized genetic syndromes, over 980 gene regions of functional significance in human development, the pericentromeric regions and subtelomeres. If applicable, abnormal finding(s) are further evaluated using FISH probes targeted to the region delineated by oligonucleotide aCGH.
The test name, specimen requirements, CPT code (81229) and pricing remain unchanged. In most cases, insurance pre-authorization is required before testing can be performed.
Any questions regarding the chromosomal microarray analysis may be directed to Dr. Timothy Drumheller, Cytogenetics Director or Lynn Vander Laan using the “Contact Us” link above.
- Array Comparative Genomic Hybridization (aCGH), Constitutional – Epic #LAB3308, CPT 81229, Interface #11551