Chemistry, Main lab

Updated: Reference Range Adjustment: C-Reactive Protein (CRP)

On May 1, 2017, Spectrum Health Regional Laboratory adjusted the reference range for C-Reactive Protein (CRP) from ≤10 mg/L to ≤5.0 mg/L.

  • The reference range  for routine CRP was changed to the one recommended by the vendor (Roche).
  • The previous range was the one recommended by the previous vendor (Spectrum Health Regional Laboratory “SHRL”, switched in 2011). At the time, the range was not changed because both methods compared very well with each other and a modification was not thought to be necessary at the time.
  • Currently, the regional hospitals are switching (or have switched) to Roche, so it was decided by laboratory leadership to modify the CRP reference range at SHRL, Grand Rapids to the standard being used across the entire system.
  • Of note, a quick survey of institutional CRP reference ranges via the internet revealed a range of upper limits including 5, 8 or 10. Mg/L
  • Of note, with respect to Chemistry, when the instrument roll out to the regional hospitals is completed; methods, ranges and results will all be the same eliminating any potential confusion that might occur from subtle vendor biases from instrument to instrument.

Any questions concerning this change may be directed to Dr. David Alter via the “Contact Us” link.


C-Reactive Protein (CRP) Blood Level (SH#8485, Epic #LAB149, CPT code 86140)


This post was updated 6/19/2017 to reflect the reasons this change was made. Original post was May 1, 2017.
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