New Reflex Test Available: Immature Platelet Fraction

In our constant effort to provide Spectrum Health with the best tools for patient care through latest innovations and cutting edge technology, we are excited to announce that the Spectrum Health Regional Laboratory will begin using new Sysmex hematology parameters.

The test is an extension of the traditional Complete Blood Count (CBC) and requires no additional blood sample. The CBC results will now provide an Immature Platelet Fraction (IPF) when the platelet count is < 75,000 /uL

Parameter Reference Range
Immature Platelet Fraction (IPF) 0.9 – 8.5%

More information on each parameter can be found below and in references provided at the end of this post. Should you have any questions about these tests please contact the laboratory via the “contact us” link above.

Immature Platelet Fraction (IPF): Immature platelet fraction (IPF) is a direct indicator of bone marrow thrombopoietic activity that may aid clinicians in the evaluation of thrombocytopenia. The IPF is useful in determining whether the thrombocytopenia is secondary to decreased production or peripheral destruction of the platelets. Different studies showed that patients with peripheral platelet destruction (such as ITP, TTP) have significantly higher IPF than those with marrow suppression.

IPF is a good predictor of platelet recovery and can be used to monitor the patients rebounding from hematopoietic progenitor cell (HPC) transplantation or chemotherapy.


Immature Platelet Fraction – No test codes available, reflex testing – CPT 85055

Complete Blood Count (CBC) with Differential – SH#8411, EPIC #LAB293, CPT 85025

Complete Blood Count (CBC) with Manual Differential – SH#8398, EPIC #LAB2111032, CPT 85027, 85007


Kickler TS, Oguni S, Borowitz MJ. Clinical evaluation of high fluorescent platelet fraction percentage in thrombocytopenia. Am J Clin Pathology 2006;125:282-287.

You Tube video https://www.youtube.com/watch?v=zcBxQnDDtAc

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