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Advanced Technology Laboratory

Advanced Technology Laboratory, Flow Cytometry

Oxidative Burst by Flow Cytometry Update

Effective immediately, Oxidative Burst by Flow Cytometry (#LAB2111414) will no longer require submission of the biological mother’s sample. An adult control specimen will still be required along with the patient’s specimen. For more information on specimen collection, please visit the Laboratory Catalog.

Questions may be directed to the Flow Cytometry Laboratory using the “Contact Us” link above.

Advanced Technology Laboratory, Molecular Diagnostics

Methods update on BCR-ABL1 t[9;22] RT-PCR testing

An updated BCR-ABL1 t[9;22] RT-PCR assay went live on Jan 31, 2018. The BCR-ABL major and minor fusion transcripts are measured and reported separately after this update. The quantities of BCR-ABL1 major breakpoints fusion transcripts (type e13a2 and/or e14a2) are detected by FDA approved QuantideX® qPCR BCR-ABL IS Kit and the result is calibrated and reported on the International Scale (%IS). The quantities of BCR-ABL minor fusion transcripts are detected by QuantideX qPCR BCR-ABL minor kit and the result is reported as BCR-ABL1 to ABL1 ratio (%). This update provides more precise and standard measurements of BCR-ABL fusion RNA and supports the consistency of patient care in t(9;22) positive CML patients during monitoring of treatment with Tyrosine Kinase Inhibitors (TKIs).

Questions may be directed to the Molecular Diagnostics Laboratory using the “Contact Us” link above.

Lab Catalog link: LAB3222022: BCR-ABL1 t[9;22] RT- PCR  

Advanced Technology Laboratory, Flow Cytometry, General Information

PNH Flow Cytometry Test Results

High sensitivity flow cytometry testing for paroxysmal nocturnal hemoglobinuria (PNH) is a test done on patient’s peripheral blood to screen for the presence or absence of PNH clones and/or to follow PNH clonal populations.  The lower limit of detection of a PNH clone for the Spectrum Health laboratory has been validated as 0.01% (1:10,000) for red cells, 0.01% (1:10,000) for granulocytes and 0.1% for monocytes (1:1000).

The results from PNH flow cytometry testing can guide the clinical team in classifying a patient’s disease appropriately, analyzing the risk of disease progression, and choosing appropriate testing to monitor response to treatment. Therefore, the PNH flow cytometry test result will now include a pathologist’s interpretation based on the new recommendations given in Updated ICCS/ESCCA Consensus Guidelines for the Clinical Utility of Testing for GPI-Anchor Deficient Clones in Paroxysmal Nocturnal Hemoglobinuria (PNH) and other Bone Marrow Disorders (Accepted article by Dezern and Borowitz, doi: 10.1002/cyto.b.21608).

Advanced Technology Laboratory, Flow Cytometry

Flow Cytometry Laboratory Attains Status as a Children’s Oncology Group Approved Laboratory

The Spectrum Health Flow Cytometry Laboratory is pleased to announce that it has attained status as a Children’s Oncology Group (COG) approved laboratory for minimal residual disease (MRD) testing for patients with B lymphoblastic leukemia (B-ALL). This is a reflection of the expertise and dedication of the entire flow cytometry team to accomplish this 3-year project. It also highlights the strong support and collaboration between the laboratory and pediatric hematology oncology team. Continue Reading

Advanced Technology Laboratory, Molecular Diagnostics

New Test: Epi proColon Septin 9 Methylation Analysis

epi procolon collectionSpectrum Health Advanced Technology Laboratories are proud to announce that the first and only FDA-approved blood test for colorectal cancer screening is now available at Spectrum Health Molecular Diagnostics Laboratory. The  Epi proColon Septin 9 Methylation Analysis test is indicated to screen adults of either sex, 50 years or older, defined as average risk for colorectal cancer (CRC), who have been offered and have a history of not completing CRC screening. Continue Reading

Advanced Technology Laboratory, Flow Cytometry

Test Discontinuation: Cell Hold by Flow Cytometry

As of 1/1/2017, the Flow Cytometry Laboratory at Spectrum Health Advanced Technology Laboratories will no longer accept specimens on hold.  The orderable Cell Hold by Flow Cytometry has been queued for inactivation. If a sample is received on hold after 1/1/2017, the ordering provider will be contacted for clarification, and appropriate testing will be performed based on the type of sample received. 

 

Advanced Technology Laboratory, Cytogenetics, Flow Cytometry, General Information, Molecular Diagnostics

Spectrum Health Advanced Technology Laboratory featured on WXMI, Fox 17

Spectrum Health Regional Laboratory (SHRL) was featured on Medical Moment on Fox 17 News, Monday, September 19, 2016. Watch the clip below to go behind the scenes of our Advanced Technology Laboratories with Kim Collison, Director of Laboratory Services. Learn how ATL provides rapid turn-around of unique testing performed right here in West Michigan, which supports many key services such as oncology.

For more information on the testing that SHRL and ATL offer, please visit our Laboratory Catalog.