General Information, Immunochemistry, Main lab, Test Utilization

Protein Electrophoresis Testing Update

In December, serum and urine protein electrophoresis testing will be simplified and standardized.  The only testing available will be:

Protein electrophoresis, serum, IFE if indicated 

Protein electrophoresis, random urine, do IFE if indicated 

Protein electrophoresis, 24 hour urine, do IFE if indicated 

In addition, on December 5, 2019, a new panel will be added which reflects expert recommendations for first line testing for monoclonal gammopathy, including plasma cell myeloma and most cases of amyloidosis, called “Monoclonal Gammopathy Screen

Protein electrophoresis, serum, IFE if indicated 

Kappa and lambda free light chains 

Stand-alone protein electrophoresis and stand-alone immunofixation testing orderables will be discontinued and replaced by the above orderables.  This change serves to ensure that the best testing is performed for all patients, especially decreasing unnecessary upfront immunofixation testing and implementing appropriate reflex testing in the laboratory.  This approach aligns to the recommendations from multiple societies for screening and follow-up for monoclonal gammopathy. This is similar to the approach utilized by Mayo Medical Laboratories and recommended by Blood and Up to Date algorithms. These changes have been reviewed and approved by the Spectrum Health Medical Executive Committee.

Questions and inquiries may be directed to the Immunochemistry department using the “contact us” link above.

REFERENCES

Ronald S. Go and S. Vincent Rajkumar “How I manage monoclonal gammopathy of undetermined significance” Blood. 2018;131(2):163-173). doi:10.1182/blood-2017-09-807560

TEST INFORMATION

Available testing

Protein Electrophoresis, Serum, IFE if Indicated – Epic #LAB844, Interface #10811, CPT #84165*

Protein Electrophoresis, Random Urine, do IFE if Indicated – Epic #LAB2111445, Interface #11510, CPT #84166*

Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated – Epic #LAB2111444, Interface #11509, CPT #84166*

Kappa and Lambda Free Light Chains – Epic #LAB3114, Interface #11083, CPT #83883 x2

Monoclonal Gammopathy Screen – Epic #LAB1230573, Interface #1230573, CPT 83883 x2, 84165*

Discontinued Testing

Protein Electrophoresis, Serum – Epic #LAB119, Interface #10232, CPT #84165*

Protein Electrophoresis, Random Urine – Epic #LAB438, Interface #10516, CPT #84166*

Protein Electrophoresis, 24 hour Urine – Epic #LAB10156, Interface #10234, CPT #84166*

The following tests will only be available for the Laboratory to order

Immunofixation, Serum – CPT #86334*

Immunofixation, Urine – CPT #86335*

*Additional professional codes for pathologist interpretation may be added

Previous Post Next Post

You Might Also Like

No Comments

Leave a Reply

five × 3 =